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KMID : 0369820170470060559
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Jorunal of Korean Pharmaceutical Sciences
2017 Volume.47 No. 6 p.559 ~ p.574
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Encapsulation of vitamin E acetate to convert oil to powder microcapsule using different starch derivatives
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Gangurde Avinash Bhaskar
Ali Meer T.
Pawar Jaywant N.
Amin Purnima Dhanraj
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Abstract
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Vitamin E (VE) is highly lipophilic in nature with a very low water solubility which degrades rapidly in presence of oxygen, and free-radical mediated oxidative processes. Spray drying of oil-in-water emulsions containing hydrophilic carriers was used to encapsulate lipophilic compounds into powders. The purpose of this study was to prepare microcapsules of VE using different starch derivatives to increase its stability and to disperse it in aqueous environment. Emulsion of VE acetate was prepared using cremophore RH 40 with tween 80 in a homogenizer and then spray dried. The spray process was optimized using a central composite design for two variables to obtain microcapsules with desirable characteristics. Microcapsules containing 2, 4 and 6% w/w of VE acetate were produced. The microcapsules were evaluated for their physical, morphological, in vitro release, solid state characterization such as SEM, FTIR, P-XRD and its in vitro free radical scavenging activity. The results showed that obtained microcapsules are nearly spherical in shape with mean particle size of microcapsules were ranged from 1 to 12 μm. The drug content and encapsulation efficiency (53?63%) was found to be uniform and within acceptable range. Optimized formulations were kept for 3 months stability study and found to be stable.
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KEYWORD
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Vitamin E acetate, Microencapsulation, Spray drying, Design of experiment, Starch derivatives
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